Colorado State University

Sponsor: Richard Titus

"Leishmaniasis Disease and It’s Effect on Humans."

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State University of New York - Binghamton, N.Y.

Sponsor: Robert Van Buskirk

"Cell Viability Improves Following Inhibition of Cryopreservation-Induced Apoptosis."

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University of Illinois

Sponsor: David Ucker

"Distinct Modes of Macrophage Recognition for Apoptotic and Necrotic Cells Are Not Specified Exclusively by Phosphatidyleserine Exposure."

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University of Montana

Sponsor: Deni Elliott

"Feelings, Beliefs and Values About Animals in the Wild."

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University of California - Berkeley

Sponsor: Kay E. Holekamp, Ph.D. in collaboration with Dr. Steve Glickman

"Evaluation of Hormonal Status, Parasite Load, and Behavioral Correlates in Free-ranging Spotted Hyenas (Crocuta crocuta)."

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St. John’s University, New York

Sponsor: Sue M. Ford

"Development of a Human Kidney Cell Line Model for the Assessment of Antiviral Drug Transport."

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University of British Columbia

Sponsor: David Fraser

"Governance of Experimental Animal Use in Canada: The Effectiveness in Reaching Ethical Goals."

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Illinois State University

Sponsor: Valeri Farmer-Dougan and Thomas Critchfield

"The Zoo as a Natural Learning Laboratory: Developing a Behavior Research and Training Unit with ISU and Miller Park Zoo."

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University of Ottawa, Canada

Sponsor: May Griffith

"Development of an Innervated Functional Human Corneal Equivalent for In Vitro Testing."

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Uppsala University, Sweden

Sponsor: Jann Hau

"Oral Immunization of Chickens for Refinement of Egg-Yolk Antibody Production: Implementation of Four R’s in Antibody Production."

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Virginia Commonwealth University

Sponsor: Masahiro Sakagami

"In Vitro Cell Monolayer-based Assay for Lung Epithelial Inflammation and Barrier Damage: Their Induction by Cigarette Smoke and Recovery By Pharmaceutical Aerosols."

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St. John’s University, New York

Sponsor: Frank A. Barile

"Effects of Trace Metals on Tight Junction Proteins in Cultured Caco-2 and Mouse Embryonic Stem Cells."

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Brown University

Sponsor: Jeffrey Morgan

"Microtissues in Micromolded Hydrogels: Reducing Animal Use With In Vitro Tissue Analogues."

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University of California, San Francisco and Berkeley

Sponsor: C. Anthony Hunt

"Development of a Multi-Scale, Multi-Aspect Framework and Models for In Silico Experimentation of Mammalian Organ Systems."

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Florida Agricultural and Mechanical University

Sponsor: Mandip Sachdeva

"Evaluation of Epiderm FT-200 (EFT-200) culture as an In Vitro model for skin irritation."

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University of Kentucky, Lexington, KY

Sponsor: Peter A. Crooks

"Design and Discovery of Novel Subtype-selective Nicotinic Receptor Agonists and Antagonists Utilizing Animal-free Cell Culture and Microplate Technologies."

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University of California, Berkeley, CA

Sponsor: Robert C. Spear

"Development of an Animal Replacement Assay for the Detection of Schistosoma japonicum."

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University of California - Irvine

Sponsor: Anand Ganesan

"Development of an Entirely Human Derived Skin Equivalent Model that will Replace Animal Models for In Vitro Testing of Melanoma Chemopreventive Agents."

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Colorado State University

Sponsor: Mark Zabel

"Development of a Cell Culture – based In Vitro Prion Amplification Assay as a Diagnostic Tool for Chronic Wasting Disease."

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University of California, Riverside

Sponsor: Dr. Nicole l. zur Nieden

"In Vitro Prediction of Skeletal Teratogenicity of Environmental Chemicals."

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University of California, Irvine

Sponsor: Dr. Steven George

"Development of a Patient-Specific High-Throughput Cardiac Drug-Screening Platform."

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University of California, San Francisco

Sponsor: Dr. Tejal Desai

"In Vitro 3D Flow Through System for Improved Intestinal Permeability Model."

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University of British Columbia

Sponsor: Dr. Martin McKeown

"Structural and Functional Neuroplasticity of Parkinson’s Disease Following a Sensori-motor Contingent Musical Walking Intervention (Ambulosono)."

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Wyss Institute for Biologically Inspired Engineering at Harvard University

Sponsor: Dr. Donald Ingber

"Human Cancer-on-a-Chip as a Replacement for Animal Testing."

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University of Texas at Austin

Sponsor: Dr. Hyun Jung Kim

"Human gut inflammation-on-a-chip for replacement of animal models."

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Johns Hopkins Bloomberg School of Public Health

Sponsor: Dr. Lena Smirnova and Dr. Thomas Hartung

“Humane scientific research is the future. The revolutionary shift towards non-animal and non-cancer tissue cell lines has had a positive impact on reducing animal research. Human-relevant models can help us study mechanisms, disease pathways or genetic risk factors which, with the aid of computational tools, can be translated to human therapies, preventive measures and epidemiological findings.”

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University of California, San Francisco

Sponsor: Dr. Tejal Desai

"In vitro 3D flow through system for improved intestinal permeability model."

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Arizona State University

Sponsor: Dr. Mehdi Nikkhah

"Studying the biochemical and biophysical influences of fibroblasts on cancer invasion in a tumor-stroma on a chip."

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University of Texas at Austin

Sponsor: Dr. Hyun Jung Kim

"Human gut inflammation-on-a-chip for replacement of animal models."

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Purdue University, Weldon School of Biomedical Engineering

Sponsor: Dr. Sherry Voytik-Harbin

"Engineering Novel 3D Tumor-Stroma to Bridge the Gap Between Preclinical Models and Human Clinical Outcomes."

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University of Pittsburgh

Sponsor: Dr. Rocky Tuan

"Application of Human iPSC-derived Mesenchymal Progenitor Cells to Develop Osteochondral Microtissues for Osteoarthritis Drug Testing."

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Boston University

Sponsor: Joyce Wong

"In vitro vascularization and perfusion of human stem cell derived organoids for use in drug testing and as models of disease, development, and function."

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University of Hawaii

Sponsor: Dr. Yusuke Marikawa

"In vitro embryoid body morphogenesis to reduce animal usage burdens in teratogenicity testing and pharmaceutical drug development."

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Arizona State University

Sponsor: Dr. Mo Ebrahimkhani

"Next Generation Designer Liver Organoids (DesLO) to Model Complex Human Phenotypes with Precision"

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University of Melbourne/Murdoch Children's Research Institute, Australia

Sponsor: Dr. Andrew Sinclair

"A novel human-based in vitro model for testis development and disorders of sex development to replace the use of animal models and animal products"

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Arizona State University

Sponsor: Dr. David Brafman

“Reliance on animal models in preclinical studies may contribute, in part, to the copious failed clinical trials related to Alzheimer’s therapy. I believe a human disease model is necessary to uncover the subtleties of the disease mechanism that may be necessary for therapeutic design. Overall, the use of pluripotent stem cells allows us to address many experimental questions that would otherwise require numerous animals to examine.”

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Texas Tech University Health Sciences Center

Sponsor: Dr. Fakhrul Ahsan

"A micropattern-engraved two-compartment tissue-chip as a non-animal model for studying right ventricular hypertrophy induced by pulmonary arterial hypertension"

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University of Tubingen, Germany

Sponsor: Dr. Katja Schenke-Layland

"Towards clinical studies on mature β-cell drug testing platform"

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The Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, Northern Ireland

Sponsor: Dr. Fionnuala Lundy and Dr. Anna-Claire Devlin

"Further characterization of an in vitro human sensory neuronal model derived from dental pulp stem cells for the study of neuronal responses in chronic obstructive pulmonary disease (COPD)"

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Leiden University Medical Center, The Netherlands

Sponsor: Dr. C.J.F. Boon

"The role of corticosteroids in the pathogenesis of central serous chorioretinopathy"

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University of Melbourne, Royal Melbourne Hospital

Sponsor: Dr. Rod Luwor

"Using brain tumor organoids to evaluate efficacy of novel inhibitors"

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Wayne State University, Detroit, Michigan

Sponsor: Dr. Carolyn Harris and Dr. Bonnie Blazer-Yost

"Engineering human choroid plexus-on-a-chip as a non-animal model to advance the understanding of how hydrocephalus alters normal CSF secretion"

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Harvard University, Cambridge, Massachusetts

Sponsor: Dr. Jennifer Lewis

"Development of a Perfusable Vascularized 3D-Kidney Organoid on a Chip for Nephrotoxicity Testing"

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Karolinska Institute, Stockholm, Sweden

Sponsor: Dr. Volker Martin Lauschke

"Mechanistic Analyses of Human Hepatocyte Plasticity"

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Johns Hopkins University, Baltimore, Maryland

Sponsor: Dr. Helena Hogberg and Dr. Thomas Hartung

"3D Human iPSC-derived Brain Organoids as a Model for Developmental Neurotoxicity Assessment of Man-Made Chemicals"

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Johns Hopkins University, Baltimore, Maryland

Sponsor: Dr. Lena Smirnova

"Synaptogenesis Assay for Developmental Neurotoxicity Testing in a Human 3D Brain Model"

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Duke University, Durham, North Carolina

Sponsor: Dr. Samira Musah

"Engineered in vitro model of the human kidney for blood filtration and disease modeling"

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