"In Vitro 3D Flow Through System for Improved Intestinal Permeability Model."

Erica Schlesinger, a Ph.D. student at the University of California San Francisco working in Dr. Tejal Desai’s lab, is a new IFER grant recipient. Her project, “In vitro 3D flow through system for improved intestinal permeability model” aims to develop a model in which human intestinal cells are grown on a tubular scaffold to better mimic the microenvironment of the intestine. Fluid, containing experimental drugs, can be flowed through the system, and drug absorption can be assessed. This new model has the potential to improve upon existing in vitro approaches to study drug absorption and may reduce the use of animals as well.