Our project aims to develop and thereby demonstrate the feasibility of a new class of multi-scale, multi-aspect in silico models and an experimentation framework. The models will be prototypes designed to simulate aspects of mammalian organ systems. The research is early stage. The new class of models is expected to progressively evolve into viable alternatives to the animal derived in vitro and in vivo models used in research (especially pharmaceutical) and education. This project includes development and validation of two early stage models: the blood-brain barrier and the functional unit of the kidney.